Genetic (DNA) Testing

Summit Blvd Animal Hospital and Laser Center

4444 Summit Boulevard
West Palm Beach, FL 33406

(561)439-7900

bestpetdoctor.com

GENETIC (DNA) TESTING

Advances in canine genetic testing can now tell you whether your pet carries a gene mutation that can lead to a deadly bleeding disorder like Type 3 Von Willebrand disease. If you have a mixed breed dog, it can also reveal your pet's mixed heritage. By knowing the parentage, our veterinarians can accurately determine the genetic diseases your pet may be at risk for. As in human medicine, the potential exists for personalized medicine for veterinary patients in which medical care is tailored to the individual patient based on his or her genetics.

 

We are proud to announce the availability of genetic testing at Summit Boulevard Animal Hospital for breed identification, parentage testing, phenotype trait testing such as coat color, and genetic disease testing.

 

Why you need to do genetic disease testing? Knowing that your pet has bleeding disorder like Von Willebrand, our veterinarians can pre-treat your pet prior to any surgical procedure. This pre-treating will help to prevent complications during and after surgery and help to save your pet's life and keep additional expenses away.

The following genetic tests are currently available:

  

Disease

Causative Gene

Breeds Affected

Inheritance Pattern

Arrhythmogenic right ventricular cardiomyopathy

STRN

Boxer

Autosomal dominant incomplete penetrance

Canine leukocyte adhesion deficiency

ITGB2

Irish setter

Autosomal recessive

Canine multifocal retinopathy

VMD2

Mastiff, Great Pyrenees, Coton de Tulear

Autosomal recessive

Centronuclear myopathy

PTPLA

Labrador retriever

Autosomal recessive

Cerebellar ataxia

Not stated

American Staffordshire terrier, American pit bull terrier

Autosomal recessive

Cobalamin malabsorption

Not stated

Australian shepherd, giant schnauzer

Not stated

Collie eye anomaly, choroidal hypoplasia

NHEJ1

Australian shepherd, border collie, Lancashire heeler, rough collie, Shetland sheepdog, smooth collie

Autosomal recessive

Cone degeneration

CNGB3

German shorthaired pointer, Alaskan malamute

Autosomal recessive

Cone-rod dystrophy 2

Not stated

American pit bull terrier

Autosomal recessive

Cone-rod dystrophy 3

ADAM9

Glen of Imaal terrier

Autosomal recessive

Congenital hypothyroidism with goiter

TPO

Toy fox terrier

Autosomal recessive

Congenital stationary night blindness

REP65

Briard

Autosomal recessive

Copper toxicosis

COMMD1

Bedlington terrier

Autosomal recessive

Cyclic neutropenia

AP3B1

Collie

Autosomal recessive

Cystinuria

SLC3A1

Newfoundland, Labrador retriever

Autosomal recessive

Degenerative myelopathy

SOD1

To many to list (all breeds can be tested)

Autosomal recessive

Dilated cardiomyopathy

PDK4

Doberman pinscher

Autosomal dominant

Dominant progressive retinal atropy

RHO

Old English mastiff, bullmastiff

Autosomal dominant

Exercise-induced collapse

DNM1

Labrador retriever, Boykin spaniel, Chesapeake Bay retriever, curly coated retriever, German wirehaired pointer, Pembroke Welsh corgi

Autosomal recessive

Factor VII deficiency

CFVII

Beagle, Airedale terrier, Alaskan klee kai, giant schnauzer, Scottish deerhound

Autosomal recessive

Familial nephropathy

COL4A4

English cocker spaniel

Autosomal recessive

Fucosidosis

FUCA

English springer spaniel

Autosomal recessive

Glanzmann?s thombasthenia

ITGA2B

Otterhound, Great Pyrenees

Autosomal recessive

Globoid cell leukodystrophy

GALC

Cairn terrier, West Highland white terrier

Autosomal recessive

Glycogen storage disease type IIIa

AGL

Curly coated retriever

Autosomal recessive

Hemophilia B

F9 (coagulation factor IX)

Bull terrier, Lhasa apso

X-linked recessive

Hereditary nephritis

COL4A5

Samoyed

X-linked dominant

Hyperuricosuria

SLC2A9

Dalmatian, black Russian terrier, beagle (all breeds can be tested)

Autosomal recessive

Ichthyosis

KRT10

Norfolk terrier, golden retriever

Autosomal recessive

Juvenile hereditary/early onset cataracts

HSF4

Boston terrier, Staffordshire bull terrier, French bulldog

Autosomal recessive

Juvenile hereditary cataracts

HSF4

Australian shepherd

Autosomal dominant-incomplete penetrance

Juvenile dilated cardiomyopathy

Unknown

Portuguese water dog

Autosomal recessive

L-2-hydroxyglutaric aciduria

L2HGDH

Staffordshire bull terrier

Autosomal recessive

Leonberger polyneuropathy

LPN1

Leonberger, Saint Bernard

Not stated

Musladin-Lueke syndrome

ADAMTSL2

Beagle

Autosomal recessive

Mucopolysaccharidosis VII

GUSB

German shepherd

Autosomal recessive

Mucopolysaccharidosis IIIB

NAGLU

Schipperke

Autosomal recessive

Mucopolysaccharidosis VI

ARSB

Miniature pinscher

Autosomal recessive

Multidrug sensitivity

MDR1

Too many to list (all breeds can be tested)

Autosomal recessive

Myotonia congenita

CLC-1

Miniature schnauzer

Autosomal recessive

Narcolepsy

HCRTR2

Dachshund, Doberman pinscher, Labrador retriever

Autosomal recessive

Neonatal encephalopathy

ATF2

Standard poodle

Autosomal recessive

Neuronal ceroid lipofuscinosis

CTSD, TPP1, CLN5, ATP13A2

American bulldog, English setter, dachshund, border collie, Tibetan terrier

Autosomal recessive

Phosphofructokinase deficiency

M-PFK

English springer spaniel, American and English cocker spaniel, whippet

Autosomal recessive

Polyneuropathy

NDRG1

Greyhound

Autosomal recessive

Primary hyperparathyroidism

Not stated

Keeshond

Autosomal dominant

Primary lens luxation

ADAMTS17

Too many to list

Autosomal recessive

Progressive retinal atrophy (RPGRIP1)

RPGRIP1

Miniature longhaired dachshund

Autosomal recessive-incomplete penetrance

Progressive retinal atrophy (PDEB)

PDEB

Cardigan Welsh corgi, Irish setter

Autosomal recessive

Progressive retinal atrophy (PRCD)

PRCD

Too many to list

Autosomal recessive

Progressive retinal atrophy (PDE6A)

PDE6A

Cardigan Welsh Corgi

Autosomal recessive

Progressive retinal atrophy (PDE6B)

PDE6B

Irish setter, sloughi

Autosomal recessive

Progressive retinal atrophy type A

Not stated

Miniature schnauzer

Autosomal dominant-incomplete penetrance

Progressive retinal atrophy X-linked

RPGR

Samoyed, Siberian husky

X-linked recessive

Pug dog encephalitis

Unknown

Pug

Autosomal recessive

Pyruvate dehydrogenase phosphate deficiency

PDP1

Clumber spaniel, Sussex spaniel

Autosomal recessive

Pyruvate kinase deficiency

R-PK

West Highland white terrier, basenji, beagle, Cairn terrier, Laborador retriever, pug

Autosomal recessive

Renal cystadenocarcinoma modular dermatofibrosis

BHD

German Shepherd

Autosomal dominant

Retinal dysplasia/oculoskeletal dysplasia

COL9A

Labrador retriever (Col9A3), Samoyed (Col9A2)

Autosomal recessive

Rod-Cone dysplasia type-2

RD3

Collie

Autosomal recessive

Severe combined immunedeficiency

IL-2RG

Basset hound, Welsh corgi

X-linked recessive

Thrombopathia

RASGRP2

Basset hound

Autosomal recessive

Von Willebrand disease type I

vWF

Bernese mountain dog, Cotton de Tulear, Doberman pinscher, Drentsche patrijshond, German pinscher, Kerry blue terrier, papillon, Pembroke Welsh corgi, poodle, stabyhoun

Autosomal recessive with incomplete penetrance

Von Willebrand disease type II

vWF

Deutsch Drahthaar, German shorthaired pointer, German wirehaired pointer, German longhaired pointer, collie, pointer

Autosomal recessive

Von Willebrand disease type III

vWF

Scottish terrier, Shetland sheepdog, kooikehondje

Autosomal recessive